ABSTRACT
Aim To study the active ingredients of essential oil in Xinjiang Ocimum basilicum L. based on system network pharmacology. Methods Information on the active ingredients of essential oil in Ocimum basilicum L. was collected from different open source databases. The functional targets together with their signaling pathway were predicted and screened. The ingredients, target proteins and their signaling pathways were established to illustrate the functional mechanism of active ingredients of essential oil in Ocimum basilicum L. against the diseases. Results Six active com-ponents of basil volatile oil were identified by analyzing the network of ingredient, target and pathway. Twenty-five main functional targets with five major pathways were also recognized. Conclusions The active components of basil essential oil mainly exert their effects on skin diseases, cancer and cardiovascular and cerebrovascular diseases through five signaling pathways.